Nick Bosa won't play Sunday

Who's in, who's out for Niners-Seahawks

Leonard Williams is good to go. He was limited Wednesday and sat out Thursday, then practiced in full Friday with no injury designation. Mykel Williams, San Francisco's edge rusher, is questionable with a knee issue after a full practice Friday, and he's expected to be activated off the reserve list in time to play.

San Francisco's bigger loss is on the other side of that same injury report. Nick Bosa is out with a knee and calf issue. Also out for the 49ers: defensive tackle James Thompson Jr., fullback Kyle Juszczyk and safety Marques Sigle. Cornerback Upton Stout is questionable with a shoulder issue.

For Seattle, linebacker Chazz Surratt (calf) and cornerback Julian Neal (hamstring) are out. Running back George Holani (ribs, knee) and wide receiver Irvin Charles (knee, designated to return from injured reserve) are questionable. Running back Zach Charbonnet is out, on the physically unable to perform list.

Team injury reports. As each club filed them. Collected 2026-10-09T22:55:02+00:00 UTC.

Team injury reports

Final keys

1San Francisco is the best team in the league by the numbers entering Sunday. The 49ers rank 1st in point differential at plus 14.5 a game and 1st in net EPA per play at plus 0.278, both ahead of Seattle's own plus 8.0 and plus 0.154.

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2Seattle's run game has to find itself. It ranks 27th in the league in EPA per rush and 30th in rush DVOA against defense. San Francisco's run defense is strong by DVOA, 7th in the league, so this is Seattle's own ground game to fix, not a soft matchup to exploit.

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3San Francisco's defense pressures the quarterback on 25.8% of dropbacks entering the game, 24th in the league, and it will try without Nick Bosa. The defensive end is out with a knee and calf issue, the kind of edge-rush loss that can turn a middling pass rush quieter.

nflverse, FTN, Sumer Sports

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Mykel Williams, questionable Sunday, made his NFL debut against Seattle

San Francisco's first-round pass rusher made his NFL debut against Seattle. Here's how that game went, and what his season has looked like since.

San Francisco is 4-0. The matchups say it should have been closer.

San Francisco is 4-0. Using the moneylines set before each game as the market's own forecast, the 49ers were expected to win about 2.68 games across those four. They have 4, a gap of plus 1.32 wins over what the lines had them down for.

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The value is front-loaded. San Francisco opened as a plus 180 underdog at the Rams and won by 20. Three weeks later, as a minus 395 favorite against Arizona, it needed a 36-30 win, a far smaller margin over what the line expected.

San Francisco's defense opened the season allowing minus 0.265 EPA per play against the Rams, the best game of its four. In the three games since, it has allowed minus 0.001, then plus 0.169, then plus 0.089 EPA per play, against Miami, Arizona and Denver.

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The offense has carried the record. San Francisco's offense ranks 1st in the league in EPA per play this season, at 0.287.

Seattle is favored by 3 points Sunday, down from 3.5 when the line opened. The market isn't treating an unbeaten, top-ranked offense as a lock on the road.

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Brian Fleury's offense, one month into year one

Seattle's offense looks almost nothing like last year's in two specific ways. The bottom line hasn't moved much at all.

The 2026 rookie class, four weeks in

This year's Day 3 picks are the best Day 3 class in five years. The first round is the weakest first round of the same five.

How Seattle is using Rashid Shaheed

He's running go routes more than any other route in his tree. The production hasn't caught up yet.